Overview
Synthetic version of naturally occurring thymosin beta-4. Promotes tissue regeneration, wound healing, and reduces inflammation.
Approval status across major regulatory agencies worldwide.
Mechanism of Action
Promotes cell migration and differentiation, upregulates actin, stimulates angiogenesis, reduces inflammation via NF-κB pathway modulation.
Stability & Storage
| Form | Storage Conditions | Shelf Life |
|---|---|---|
| Lyophilised (Freeze-Dried) |
Store lyophilized powder at -20°C for long-term storage (12-24 months). Can be stored at 2-8°C for up to 6 months. Protect from light. | 12-24 months |
| Reconstituted Solution |
After reconstitution with bacteriostatic water, store at 2-8°C for up to 21-28 days. With sterile water, use within 5-7 days. Avoid freeze-thaw cycles. | 21-28 days |
- Always store in original packaging until ready to use
- Protect from light, moisture, and temperature fluctuations
- Never refreeze after thawing
- Use proper sterile technique when reconstituting
- Discard if solution becomes cloudy or discolored
Target Information
- Connective tissue
- muscle tissue
- epithelial tissue
- vascular endothelium
- neural tissue
- Heart
- skeletal muscle
- tendons
- ligaments
- skin
- blood vessels
- brain
- gastrointestinal tract
Pharmacokinetics: Half-Life by Administration Route
The biological half-life varies significantly depending on the route of administration. This affects dosing frequency and duration of action.
| Administration Route | Half-Life | Clinical Implications |
|---|---|---|
| Intravenous (IV) | Approximately 2 hours when administered intravenously based on clinical pharmacokinetic studies | Direct bloodstream entry, fastest onset, shortest duration |
| Subcutaneous (SC) | Approximately 2.4 hours after subcutaneous injection in circulation, with tissue residence time sign | Slower absorption, sustained release, most common route |
Note: Half-life values can vary between individuals based on factors including age, metabolism, kidney/liver function, and co-administered medications.
Molecular Structure
Amino Acid Sequence
2D Chemical Structure
2D Structure Visualization Pending
This peptide contains 43 amino acids.
For larger peptides, the amino acid sequence (shown above) provides the most accurate representation of structure.
2D chemical structure visualization is most effective for peptides with <10 amino acids.
3D Molecular Model
3D structure model will be available soon
Structure visualization powered by 3Dmol.js (integration pending)
Peptide Composition & Modifications
Amino Acid Composition
Terminus Modifications
Terminal modifications can protect against exopeptidase degradation and modulate biological activity.
Nomenclature
- Thymosin Beta-4
- Tβ4
- TB4
- Thymosin β4
Dosage & Administration
Research doses: 2-10 mg weekly, SC
This information is for educational purposes only. Dosing should only be determined by a qualified healthcare provider based on individual patient needs and medical history.
Scientific References
References are organized by topic for easy navigation. Click on PubMed links to view the full articles.
Clinical Trials
Mechanism of Action
Wound Healing
Research & Clinical Status
FDA approved for veterinary use. Human trials ongoing.
Disclaimer
This information is for educational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before starting any new treatment or medication. The information provided here is based on available scientific literature and may not be complete or up-to-date.